Ketamine, originally developed as an anesthetic, is now used in both medical and recreational contexts. However, patterns of harmful ketamine use are on the rise, particularly due to its use in unregulated clinics — marketed as a “psychedelic” – though it’s actually an anesthetic dissociative with known hallucinogenic effects.
Recognizing the signs of ketamine misuse is crucial for preventing serious harm, as prolonged misuse can lead to significant psychological and physical consequences.
1. Behavioral Signs of Harmful Ketamine Use
- Mood Swings: Individuals misusing ketamine may exhibit unpredictable mood changes, ranging from euphoria and calmness to anxiety, irritability, and depression.
- Isolation: Those misusing ketamine may withdraw from social interactions or neglect responsibilities like work or school due to its dissociative effects.
- Memory Issues: Frequent users often struggle with short-term memory loss and cognitive impairments, affecting their ability to function effectively in daily life.
2. Physical Signs of Harmful Ketamine Use
- Slurred Speech and Motor Impairment: Ketamine users often exhibit poor coordination, slurred speech, and difficulty moving, which can resemble intoxication.
- Frequent Bladder Issues: Ketamine is known to cause bladder problems (ketamine bladder syndrome), resulting in painful urination, frequent urination, or even incontinence.
- Hallucinations: Visual or auditory hallucinations, as well as vivid dreams or altered sensory perceptions, can be signs of ketamine misuse.
3. Materials and Methods of Harmful Ketamine Use
- Powder or Liquid Forms: Ketamine is typically available in a white powder or clear liquid form. Finding small vials, powdered residue, or drug paraphernalia (e.g., needles, spoons) can be an indicator of misuse.
- Unusual Odor: Ketamine has a distinct chemical odor. If you notice an unusual smell on a person or their belongings, it may signal its use.

4. Psychological Indications of Harmful Ketamine Use
- Detachment from Reality: Frequent dissociation or “out of body” experiences can indicate ketamine misuse. Individuals may seem disconnected from their surroundings or experience a detachment from themselves.
- Depression and Anxiety: After the effects wear off, ketamine users may experience increased anxiety or depression, which can worsen with repeated use.
5. Risk-Taking Behavior with Harmful Ketamine Use
- Engaging in Dangerous Activities: Misuse can lead to impaired judgment and risky behaviors, such as driving under the influence or engaging in unprotected sex. The user may underestimate the dangers due to the drug’s effects.
6. Increased Tolerance and Dependence Associated with Harmful Ketamine Use
- Higher Doses Needed: Misuse often leads to increased tolerance, where the individual requires larger amounts of ketamine to achieve the desired effects. This is a strong indicator of dependency.
- Frequent Use: Using ketamine more often than intended, or failing to stop despite wanting to, suggests addiction and misuse.
What to Do for Someone You Care About
Recognizing the signs of harmful ketamine use is essential for early intervention — before someone overdoses and dies.
Behavioral changes, physical symptoms, and risky behavior are key indicators that someone may be using ketamine in a way that is harmful. If you or someone you know is struggling with ketamine use that may be verging on harmful, it’s important to seek professional help to prevent long-term damage to health and well-being.
Many medical doctors and ketamine clinics are utilizing ketamine as an off-label treatment for addiction. However, not all addiction specialists are well-versed in the complexities of addressing harmful ketamine use.
At Enthereal, we understand that compassionate and appropriately aligned care is crucial in supporting someone facing ketamine misuse. If you are concerned about a loved one, contact us for recommendations on clinicians who are experienced in delivering empathetic, effective treatment tailored to addressing the harms associated with ketamine misuse.
We’re here to help guide you toward the right support on the journey to recovery.